Synthesis of methyl derivatives of linear and angular thienocoumarins and thiopyranocoumarins

✍ Scribed by P. Rodighiero; G. Pastorini; A. Chilin; A. Marotto

• Book ID: 102339394
• Publisher: Journal of Heterocyclic Chemistry
• Year: 1998
• Tongue: English
• Weight: 470 KB
• Volume: 35
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570350411

✦ Synopsis

Abstract

New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7‐mercaptocoumarin, which were condensed with chloro‐ketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine which methods produced the best yields of the desired thienocoumarins 15, 16, 17, 18, 22, 23, 24, 27 and thiopyranocoumarins 28 and 29.