✦ LIBER ✦

Synthesis of methyl (1R,2S)-α,α-dimethyl-3-oxo-2-pentylcyclopentaneacetate. A model procedure for the preparation of chiral jasmonoids and prostaglandins

✍ Scribed by A García Martínez; E Teso Vilar; A García Fraile; S de la Moya Cerero; P Martínez Ruiz; P.P García Álvarez

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 216 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00072-4

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✦ Synopsis

An expeditious procedure for the enantiospecific preparation of the trans-2,3disubstituted cyclopentanone moiety starting from natural 2-norbornanones is described. New reaction conditions for the reaction of sterically hindered ketones with triflic anhydride, as well as for the S-O cleavage of bridgehead triflates have been developed.

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