✦ LIBER ✦

Synthesis of methoxy and hydroxy containing tetralones: versatile intermediates for the preparation of biologically relevant molecules

✍ Scribed by Anjan Ghatak; James M. Dorsey; Charles M. Garner; Kevin G. Pinney

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 141 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00715-9

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihydroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest.

📜 SIMILAR VOLUMES

Synthesis of Methoxy and Hydroxy Contain

Synthesis of Methoxy and Hydroxy Containing Tetralones: Versatile Intermediates for the Preparation of Biologically Relevant Molecules.

✍ Anjan Ghatak; James M. Dorsey; Charles M. Garner; Kevin G. Pinney 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 103 KB 👁 2 views

Chiral Oxazolopiperidone Lactams: Versat

Chiral Oxazolopiperidone Lactams: Versatile Intermediates for the Enantioselective Synthesis of Piperidine-Containing Natural Products

✍ Carmen Escolano; Mercedes Amat; Joan Bosch 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB 👁 1 views

Chiral Oxazolopiperidone Lactams: Versat

Chiral Oxazolopiperidone Lactams: Versatile Intermediates for the Enantioselective Synthesis of Piperidine-Containing Natural Products

✍ Carmen Escolano; Mercedes Amat; Joan Bosch 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 600 KB

2-Methoxy-5-methylphenyl Thiosemicarbazi

2-Methoxy-5-methylphenyl Thiosemicarbazide (I): A Versatile Molecule for the Synthesis of Thiadiazoles (III) and Imidazolinones (V) Possessing Multiple Biological Activities.

✍ S. B. Hirpara; K. A. Parikh; B. C. Merja; H. H. Parekh 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 111 KB 👁 2 views

ChemInform Abstract: Stereoselective Syn

ChemInform Abstract: Stereoselective Synthesis of a Versatile Intermediate for the Total Synthesis of Mono- and Bis-THF Containing Annonaceous Acetogenins.

✍ Shyi-Tai Jan; Keqiang Li; Shikha Vig; Alexander Rudolph; Fatih M. Uckun 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

ChemInform Abstract: Enantioselective Al

ChemInform Abstract: Enantioselective Allyltitanations. Synthesis of Optically Active 1,2-Diol Units: Useful Intermediates for the Preparation of Biologically Active Compounds.

✍ Janine Cossy; Samir Bouzbouz; Jean Claude Caille 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views