✦ LIBER ✦
Synthesis of [methine-3H]ddt and its nitro-analog, and isotope effects in their enzyme-catalyzed dehydrochlorination
✍ Scribed by N. Kurihara; Y. Ikemoto; S. Okutani; A. G. Clark
- Book ID
- 102371826
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 312 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
3 [methine-H]1,l-Di-(4-chlorophenyl)-2,2 2 -t r i c h l o r o e t h a n e ([methine-HIDDT) and i t s d i -( 4 -n i t r o p h e n y l ) analog, b o t h o f h i g h p u r i t y w i t h a moderately h i g h s p e c i f i c a c t i v t y were prepared. Chloro-3 benzene was condensed w i t h [l-H]1-(4-chlorophenyl)-2,2,2-trichloroethanol, which had been synthesized by sodium boro[ H l h y d r i d e reduct i o n o f 4-chlorophenyl t r i c h l o r o m e t h y l ketone. The p u r i f i e d [3H]DDT had a s p e c i f i c a c t i v i t y o f 0.77 Ci/mmol (28.49 GBq/mmol).