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Synthesis of Metabolites of the Ah Receptor Ligand 6-Formylindolo[3,2-b]carbazole

✍ Scribed by Niklas Wahlström; Ivan Romero; Jan Bergman

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
182 KB
Volume
2004
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Synthesis of the five mono‐ and di‐hydroxylated metabolites of the aryl hydrocarbon receptor high affinity ligand 6‐formylindolo[3,2‐b]carbazole is described. The structures of the metabolites were unequivocally established as 2‐hydroxy‐, 8‐hydroxy‐, 2,10‐dihydroxy‐, 4,8‐dihydroxy‐ and 2,8‐dihydroxyindolo[3,2‐b]carbazole‐6‐carboxaldehyde. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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