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Synthesis of meso-2,4-diaminoglutaric acid.

✍ Scribed by Alberto Avenoza; Carlos Cativiela; Jesús M. Peregrina; María M. Zurbano


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
222 KB
Volume
7
Category
Article
ISSN
0957-4166

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📜 SIMILAR VOLUMES


Asymmetric synthesis of meso- and (2R,4R
✍ Alberto Avenoza; Carlos Cativiela; Jesús M. Peregrina; María M. Zurbano 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 569 KB

In order to synthesize mesoand (2R,4R)-2,4-diaminoglutaric acids, a synthetic route has been developed starting from Garner's aldehyde and where the key steps are the asymmetric hydrogenations of (E)-and ethenyl]-l,3-oxazolidine, under heterogeneous conditions, followed by oxidation and further hyd

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## Abstract A new synthesis of orthogonally protected diaminoglutaric acid containing peptides using the Ugi four component condensation is presented. To demonstrate that this method is useful to replace cystine by diaminoglutaric acid in biologically interesting peptides, we built up two cyclic so