In order to synthesize mesoand (2R,4R)-2,4-diaminoglutaric acids, a synthetic route has been developed starting from Garner's aldehyde and where the key steps are the asymmetric hydrogenations of (E)-and ethenyl]-l,3-oxazolidine, under heterogeneous conditions, followed by oxidation and further hyd
✦ LIBER ✦
Synthesis of meso-2,4-diaminoglutaric acid.
✍ Scribed by Alberto Avenoza; Carlos Cativiela; Jesús M. Peregrina; María M. Zurbano
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 222 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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## Abstract A new synthesis of orthogonally protected diaminoglutaric acid containing peptides using the Ugi four component condensation is presented. To demonstrate that this method is useful to replace cystine by diaminoglutaric acid in biologically interesting peptides, we built up two cyclic so