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SYNTHESIS OF MEBENDAZOLE AND ENVIROXIME. ACYLATION OF 2-AMINO-5-BENZOYLBENZIMIDAZOLE

✍ Scribed by Ravindranathan, T.; Wakharkar, R. D.; Landge, A. B.


Book ID
120423565
Publisher
Taylor and Francis Group
Year
1987
Tongue
English
Weight
326 KB
Volume
19
Category
Article
ISSN
0030-4948

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## Abstract Acylation of 5‐amino‐3__H__‐1,3,4‐thiadiazolin‐2‐one (2) was undertaken selectively at either the 3‐NH position or at 5‐amino group depending on reaction conditions. The 3‐NH is highly acidic and acylation takes place with acid anhydrides at this position in high yields in the presence