Synthesis of Malonaldehyde Monoacetals

✍ Scribed by Shi-Qi, Peng ;Winterfeldt, Ekkehard

• Book ID: 102365197
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 245 KB
• Volume: 1989
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.198919890264

✦ Synopsis

Malonaldehyde is a very useful building block in organic synthesis. Of particular interest are its monoacetals, as they allow for sequential use of the aldehyde groups at selected steps of the synthetic pathway. Few methods of general applicability are reported in the literature for the preparation of malonaldehyde monoacetals, which were reviewed by Botteghi and Soccolini'). Owing to the need for various monoacetals of malonaldehyde in our research

, b, d, e --+ [ CH, ] )-CH, -CHO 5a, b, d, e 1 + HO-CH,-c(cH,),-CH,-OH --+ 3c 4c 0 3c + >c t C H 2 -c H O 0 1 + HS-CH(CH~)-CH,-SH