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Synthesis of macrocyclic terpenoids by intramoleclar cyclization II germaclane-type sesquiterpenes

✍ Scribed by Mitsuaki Kodama; Yasuo Matsuki; Shô Itô

Publisher: Elsevier Science
Year: 1976
Tongue: French
Weight: 192 KB
Volume: 17
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)93767-5

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✦ Synopsis

In the previous paper (l), we hove described the biogenetic-type synthesis of diterpenes with a fourteen-membered ring, cembrene-A and nephthenol, exemplifying usefulness of the anion-induced intramolecular cyclizarion in the synthesis of macrocyclic terpenoids. We have applied the general reaction sequence to the synthesis of sesquiterpenes, where this type of cyclization is more important biogenetic pathway than in diterpenes. This communicarion deals with a convenient and highly selective synthesis of sesquiterpenes with ten-membered ring which would be quite laborious to construct by other methods (2).

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