Synthesis of Long-chain 1-Alkylimidazole-2-thiols, 1-Alkylimidazoles, and Some Related Benzimidazole Compounds

✍ Scribed by Bäuerlein, Edmund ;Trasch, Heinz

• Book ID: 102899627
• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 521 KB
• Volume: 1979
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.197919791120

✦ Synopsis

Abstract

This article describes the synthesis of long‐chain 1‐alkylimidazole‐2‐thiols 3 and 1‐decylbenzimidazole‐2‐thiol (10), of value as nucleophilic scavengers for sulfenyl groups (RS^+^) in lipophilic membranes^2)^ and as inhibitors of thyroid peroxidase^3)^, as well as of the corresponding 1‐alkylimidazoles 6 and ‐benzimidoles 7. Because 1‐decyl compounds belonging to the benzimidazole series apparently have a specific action on proton translocation in the mitochondrial system, which depends on their basicity^2)^., the half‐neutralisation potentials of 7c, 10 and 11 have been determined in aqueous acetonitrile.