Synthesis of lipophilic crown ethers with pendant carboxylic acid groups
β Scribed by Bronislaw P. Czech; Anna Czech; Byungki Son; Han Koo Lee; Richard A. Bartsch
- Book ID
- 112128171
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1986
- Tongue
- English
- Weight
- 721 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-152X
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## Abstract A sixβstep synthetic route to four lipophilic crown ethers with intraannular carboxylic acid groups and ring sizes of 15βcrownβ4, 18βcrownβ5, 21βcrownβ6 and 24βcrownβ7 is described. Eight new polyether compounds that bear inwardβfacing bromo and formate ester substituents are prepared a
## Abstract Synthetic routes to sixteen lipophilic lariat ether __N__β(X)sulfonyl carboxamides with X = trifluoromethyl, methyl, phenyl, and __p__βnitrophenyl are described. For this new family of protonβionizable lariat ethers in which the acidity can be βtunedβ by X group variation, the ring size