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Synthesis of Linear Annulated Tricyclic Heterocycles Incorporating the Pyrazolo[3,4-d]pyrimidine Skeleton

✍ Scribed by Svêtlík, Jan

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 235 KB
Volume: 1987
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.198719870884

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Friedländer condensation of 5-aminopyrazole-4-carbaldehydes 1 with formamide 2a or benzamide 2b gave pyrazolo [3,4-d]pyrimidine derivatives 3. Cyclocondensation of 1 with cyclopentanone, N-benzyl-4piperidone and 6-methoxy-1-tetralone yielded cyclopenta[b]pyrazolo[4,3-e]pyridines 4, pyrazolo[3,4-b]-[