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Synthesis of lidocaine-d3

✍ Scribed by Charles E. Hignite; Christian Tschanz; David H. Huffman; Daniel L. Azarnoff

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
227 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simple two step synthetic procedure has been developed for the preparation of deuterated lidocaine. The deuterium was incorporated into the 6′‐methyl group which is a metabolically stable position. The overall yield of the synthetic procedure was 41.3%.

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