✦ LIBER ✦
Synthesis of labeled (10R)-Juvenile hormone III bisepoxide, and its photoaffinity analog, [12-3H]-(10R)-6,7,10,11-bisepoxyfarnesyl diazoacetate (BEFDA)
✍ Scribed by Bachir Latli; Glenn D. Prestwich
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 392 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Radiolabeled optically‐active JH III bisepoxide ([^3^H]‐(10__R__)‐JHB~3~) was synthesized from [12‐^3^H] (10__R__)‐JH III using dimethyldioxirane to give an inseparable mixture of diastereomers with the trans‐6,7‐epoxide syn or anti to the existing 10,11‐epoxide. [^3^H]‐(10__R__)‐JHB~3~ (or the unlabeled material) was converted in three steps to the corresponding (10__R__)‐6,7,10,11‐bisepoxyfarnesyl diazoacetate (BEFDA), a photoaffinity label for JHB~3~ receptors and binding proteins.