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Synthesis of L-3'-azido-3'-deoxythymidine (L-AZT) and its stereoisomers

✍ Scribed by Wengel, Jesper; Lau, Jesper; Pedersen, Erik B.; Nielsen, Carsten M.


Book ID
127391585
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
577 KB
Volume
56
Category
Article
ISSN
0022-3263

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An efficient total synthesis of 3β€²-azido
✍ Chung K Chu; J.Warren Beach; Giliyar V Ullas; Yoshiyuki Kosugi πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 231 KB

An efficient stereoselective total synthesis of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZDDU, CS-87) from readily available and inexpensive starting material, D-mannitol has been achieved. 3'-Azido-3'-deoxythymidine (AZT) has been found to be a potent antiviral agent ag