Synthesis of L-2,3,5,6-tetrafluoro-4-(phosphonomethyl) phenylalanine, a novel non-hydrolyzable phosphotyrosine mimetic and L-4-(phosphonodifluoromethyl)phenylalanine
β Scribed by Wang-Qing Liu; Bernard P. Roques; Christiane Garbay
- Book ID
- 104256400
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 249 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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The F2Pmp derivatives were prepared in 80-90% yield from commercially available protected L-4-iodophenylalanine by esterification with diazomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover, treatment of L-4-iodoPhe-containing peptides under
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