Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from α-amino acids
✍ Scribed by Michelle Groarke; Basil Hartzoulakis; M.Anthony McKervey; Brian Walker; Carvell H Williams
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 148 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
AbstractÐThe reductive amination of an amino acid derived glyoxal, with the free amino group of a protected amino acid or oligopeptide fragment, has been developed as a simple and ecient method for the preparation of ketomethylene amino pseudooligopeptide isosteres AaÉ(COCH 2 NH)Aa. Trichlorosilane±DMF is the reagent of choice for the reduction.
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