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Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from α-amino acids

✍ Scribed by Michelle Groarke; Basil Hartzoulakis; M.Anthony McKervey; Brian Walker; Carvell H Williams


Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
148 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis


AbstractÐThe reductive amination of an amino acid derived glyoxal, with the free amino group of a protected amino acid or oligopeptide fragment, has been developed as a simple and ecient method for the preparation of ketomethylene amino pseudooligopeptide isosteres AaÉ(COCH 2 NH)Aa. Trichlorosilane±DMF is the reagent of choice for the reduction.


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