✍ Scribed by Chaitanya G. Dave; Rina D. Shah
No coin nor oath required. For personal study only.
4‐Hydrazino‐7__H__‐pyrrolo[2,3‐d]pyrimidines (4) were cyclocondensed with formic acid or triethyl orthoformate to give 7__H__‐1,2,4‐triazolo[1,5‐c]pyrrolo[3,2‐e]pyrimidines (5) and 7__H__‐1,2,4‐triazolo[4,3‐c]pyrrolo‐[3,2‐e]pyrimidines (6) respectively. The [4,3‐c]‐isomers (6) were rearranged into thermodynamically more stable [1,5‐c]‐isomers (5). The identical compounds (5) were prepared using another route by reacting 3‐amino‐4‐imino‐7__H__‐pyrrolo[2,3‐d]pyrimidines (3) with formic acid or triethylorthoformate. Reaction of 2‐amino‐3‐cyanopyrroles (1) with triethyl orthoformate followed by hydrazinolysis afforded (3) via the formation of N‐ethoxymethylene‐2‐amino‐3‐cyanopyrroles (2).
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## Abstract 4‐Hydrazino‐7__H__‐pyrrolo[2,3‐__d__]pyrimidines **4** were cyclocondensed with formic acid or triethyl orthoformate to give 7__H__‐pyrrolo[3,2‐__e__][1,2,4]triazolo[1,5‐__c__]pyrimidines **6** and 7__H__‐pyrrolo[3,2‐__e__][1,2,4]triazolo[4,3‐__c__]pyrimidines **7**, respectively. The [