Synthesis of isocoumarins and α-pyrones via iodocyclization

✍ Scribed by Tuanli Yao; Richard C Larock

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 122 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01731-8

✦ Synopsis

A variety of 3-substituted 4-iodoisocoumarins and 6-substituted 5-iodo-2(2H)-pyranones are readily prepared in excellent yields under mild reaction conditions by the reaction of o-(1-alkynyl)benzoates and (Z)-2-alken-4-ynoates with ICl.