𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents

✍ Scribed by Ricardo A. Tapia; Claudia Carrasco; Scarlet Ojeda; Cristian Salas; Jaime A. Valderrama; Antonio Morello; Yolanda Repetto

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
45 KB
Volume
39
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of new indazol‐4,7‐dione derivatives via 1,3‐dipolar cycloaddition of diazomethane with 2,3‐dimethyl‐1,4‐benzoquinone (2) and 1,4‐naphthoquinone (7) followed by N‐alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described. A series of amides from esters (5) and (10) were also obtained. These compounds were tested in vitro as potential anti‐trypanosomal agents. Compounds (4) and (8) were found to have significant activity.

📜 SIMILAR VOLUMES

Synthesis of sydnonimine derivatives as
Synthesis of sydnonimine derivatives as potential trypanocidal agents
✍ Laurent Soulère; Dr. Pascal Hoffmanna; Frédéric Bringaud 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 69 KB

## Abstract __N__‐(__p__‐Nitrophenoxy)carbonyl‐3‐morpholino‐sydnonimine (NCMS) has been prepared from 3‐morpholinosydnonimine hydrochloride. Using the Griess assay and the superoxide‐mediated reduction of ferricytochrome c, the nitric oxide (NO•) and superoxide anion (O~2~•^‐^) ‐ releasing properti