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Synthesis of imidate hydrochlorides by reaction of ethyl chloroformate with amides and thionamides

✍ Scribed by Suydam, Fred H.; Greth, Warren E.; Langerman, Neal R.


Book ID
121426342
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
659 KB
Volume
34
Category
Article
ISSN
0022-3263

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Reactions of phosphoric anhydride with a
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Acyclic secondary amides such as benzanilides 1a-g, acetanilides 2a-d, and benzamide 1h undergo selfcondensation in the presence of phosphoric anhydride to produce, in one step, N-substituted aroyl benzamidines 3a-g, acyl acetamidines 4a-d, and imide 5, respectively. Mechanistic evidence is presente