Synthesis of ikarugamycin: Studies on the carbotricyclic sub-unit
β Scribed by Raymond C.F. Jones; Richard F. Jones
- Book ID
- 104222299
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 307 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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Studies into the Synthesis of a Sub-Unit of the Neurotoxic Alkaloid Methyllycaconitine. -According to the known structure-activity relationships the potentially toxophoric subunit (XVII) of the title alkaloid is synthesized. The structure of the key intermediate (XI) is determined by X-ray analysis
## Abstract The stereoβ and regiochemical course in the [2+4]cycloaddition of the chiral alkylidene malonic ester **1** to selected derivatives of (2__E__, 4__E__)β4βmethylβ2, 4βhexadienβlβol (**2**) and (2__E__, 4__E__)β4βmethylβ2, 4βhexadienβlβal (**12**) has been investigated. The results are di