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Synthesis of I-131 labelled 4-iodophenylacetic acid

✍ Scribed by Zoltan Szucs; Mike Sathekge; Biljana Marjanovic-Painter; Judith Wagener; Thato Sello; Carl Wagener; Jan Rijn Zeevaart

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
172 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Phenylacetate has been reported to have a potent anti‐proliferative and anti‐differentiating effect in haematological malignancies and in solid tumours at non‐toxic concentrations. This study is a preliminary investigation into the potential of 4‐iodophenylacetic acid radiolabelled by ^131^I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by‐product and is suitable for studies in animals. Copyright © 2010 John Wiley & Sons, Ltd.

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