Synthesis of hydroxyl silylated rhenium and (99mTc)technetium ‘3+1’ mixed ligand complexes

✍ Scribed by Torsten Kniess; Hartmut Spies; Isabel Santos; Alla Zablotska

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: French
• Weight: 102 KB
• Volume: 45
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.567

✦ Synopsis

Abstract

The synthesis of hydroxyl silylated thiols as monodentate ligands is described. These monodentates were used to build with Re and ^99m^Tc trimethyl‐, triethyl‐ and triphenyl‐silylated ‘3+1’ mixed ligand complexes, using 3thiapentane‐1,5‐dithiol as co‐ligand. The Re complexes were characterized by ^1^H NMR and elemental analysis, the ^99m^Tc complexes were detected by radio HPLC. While the trimethyl silylated derivatives hydrolysed in aqueous media, the triethyl‐ and triphenyl silylated complexes have proved to be stable in neutral solutions. Copyright © 2002 John Wiley & Sons, Ltd.