𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of hydroxyethylene dipeptide isosteres that mimic a cyclic amino acid at the P1′ subsite

✍ Scribed by J.V.N. Vara Prasad; Daniel H. Rich

Book ID
118549879
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
257 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

New synthesis of 5-amino-4-hydroxy-2,6-d
New synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a hydroxyethylene isostere of the Val-Ala dipeptide
✍ Fabio Benedetti; Paolo Maman; Stefano Norbedo 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 73 KB

Two stereoisomers of the title compound have been synthesized from the methyl ester of N-Boc L-valine. The aminoester was initially converted into an a%-amino a,b-unsaturated ketone via a phosphonoketone and a Horner-Emmons olefination with acetaldehyde. Hydrocyanation of the enone with diethylalumi

A Practical Synthesis of the Dihydroxyet
A Practical Synthesis of the Dihydroxyethylene Dipeptide Isostere, (2S, 3R, 4S) 2-[(tert-Butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, from D-Isoascorbic Acid
✍ William R. Baker; Stephen L. Condon 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 249 KB

The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p