## Pyran derivatives R 0340 Diastereoselective Synthesis of Functionalized δ-Lactones. -The diastereocontrol of the title reactions depends on the substituent of the glutarate. -(SAMARAT, A.;
Synthesis of Highly Functionalized δ-Lactone-Fused Cyclopentanoids.
✍ Scribed by Faiz Ahmed Khan; K. S. Krishnakumar; Ch. Sudheer
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 42 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract A novel and general synthesis of δ‐lactones from glutaraldehyde is described. The dialdehyde is first reacted with an alkyl or substituted alkyl __Grignard__ reagent to afford a δ‐hydroxyaldehyde in good yield. These aldehydes exist preferentially in the cyclic hemiacetal form (δ‐lactol
A series of 18 new a,&unsaturated &&&substituted &lactones was synthesized as possible therapeutic agents. The majority of the compounds described contain an aryloxy grou in the pposition of the lactone ring, while those naturally occurring in P+er mat&ticwn all contain an alkoxy group in this posit