Synthesis of high specific activity 1,8-naphthalic anhydride

✍ Scribed by Fred S. Tanaka; Ronald G. Wien; Barry L. Hoffer

• Book ID: 102901054
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: French
• Weight: 501 KB
• Volume: 21
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580210608

✦ Synopsis

T h e s y n t h e s i s o f [ 1 4 C -c a r b o x y l l l 1 8 -n a p h t h a l i c a n h ya n h y d r i d e o f h i h s p e c i f i c a c t i v i t y ( 3 1 . 8 mCi/mmol) i s r e p o r t e d . G r i g n a r d r e a g e n t , 8-bromo-1-naphthylmagnesium i o d i d e , t h a t was p r e p a r e d f r o m 8-bromo-1-iodonaphthalene. T h e o v e r a l l r a d i o c h e m i c a l y i e l d f o r t h e r e a c t i o n s c h e m e was 6 3 . 7 % b a s e d o n b a r i u m c a r b o n a t e -l 'IC. T h e lf'rC was i n t r o d u c e d by c a r b o n a t i o n o f t h e K e y w o r d s : H e r b i c i d a l a n t i d o t e , p r o t e c t a n t , s a f e n e r , r a d i ol a b e l e d s y n t h e s i s , 1 , 8 -n a p t h a l i c a n h y d r i d e .