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Synthesis of High-Molecular-Weight Poly(L-lactic acid) by Direct Polycondensation

✍ Scribed by Ki Woong Kim; Seong Ihl Woo


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
212 KB
Volume
203
Category
Article
ISSN
1022-1352

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Poly(L-lactic acid) (PLLA) was produced by the melt polycondensation of L-lactic acid. For the optimization of the reaction conditions, various catalyst systems were examined at different temperature and reaction times. It was discovered that Sn(II) catalysts activated by various proton acids can pr

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## Abstract Starting from D,L‐acid and SnCl~2~ as catalyst, poly(D,L‐lactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such as 0.5 wt % SnCl~2~, 170–180Β°C, 70 Pa, and 10 h, the viscosity‐average molecular weight (__M__~Ξ·~) of PDLLA was 4100 Da.

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## Abstract Poly(glutamic acid‐__co__‐lactic acid‐__co__‐glycolic acid) (PGLG), an amphiphilic biodegradable copolymer, was synthesized by simply heating a mixture of L‐glutamic acid (Glu), DL‐lactic acid, and glycolic acid with the present of stannous chloride. The unique branched architecture com