Synthesis of hexahydro[2]benzopyrano[3,4-c]pyrroles as serotonin 5-HT2C receptor agonists via intramolecular hetero Diels–Alder reactions
✍ Scribed by Takao Kiyoi; Mark Reid; Stuart Francis; Keneth Davies; Steven Laats; Duncan McArthur; Anna-Marie Easson; Yasuko Kiyoi; Gary Tarver; Wilson Caulfield; Kirsty Gibson; Grant Wishart; Angus J. Morrison; Julia M. Adam; Peter Ray
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 552 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract The title skeleton (II)/(III) is prepared in analogy to the pyrrole systems in the preceding paper.
A new, efficient and stereoselective synthesis of furo[2%,3%:5,6]pyrano [4,3-b]quinoline derivatives 3 and 3% has been achieved by intramolecular hetero-Diels-Alder reactions of aldimines generated in situ from aromatic amines and the O-allyl derivative of the chiral sugar derived aldehyde 2 in acet