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Synthesis of Heterocyclic-fused Imidazoles by Pyrolysis of N-Heterocyclic Isoxazol-5(2H)-ones

✍ Scribed by Abel, Steven-Alan G.; Eglinton, Mathew O.; Howard, James K.; Hunt, Dylan J.; Prager, Rolf H.; Smith, Jason A.


Book ID
125842568
Publisher
Commonwealth Scientific and Industrial Research Organisation Publishing
Year
2014
Tongue
English
Weight
506 KB
Volume
67
Category
Article
ISSN
0004-9425

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## Abstract 3‐Aryl‐1,2,4‐triazin‐5(2__H__)‐ones 1a‐c react with indoles 2a‐c in trifluoroacetic acid/chloroform or in boiling butanol or acetic acid to give 3‐aryl‐6‐(indolyl‐3)‐1,6‐dihydro‐1,2,4‐triazin‐5(2__H__)‐ones 3a‐g. Oxidation of the dihydro‐1,2,4‐triazin‐5(2__H__)‐ones 3a‐e afforded 6‐(ind