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Synthesis of hantzsch 1,4-dihydropyridines under solvent-free condition using zn[(L)proline]2 as lewis acid catalyst

✍ Scribed by V. Sivamurugan; R. Suresh Kumar; M. Palanichamy; V. Murugesan

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 65 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420534

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✦ Synopsis

Abstract

The present short communication describes a Lewis acid (Zn[(L)proline]~2~) catalysed one pot synthesis of Hantzsch 1,4‐dihydropyridine (DHP) derivatives under solvent‐free condition by conventional heating and microwave irradiation. The Lewis acid catalyst Zn[(L)proline]~2~ used in this reaction afford moderate to good yield. The catalyst is reusable upto five cycles without appreciable loss of its catalytic activity.

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