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Synthesis of GTP-Derived Ras Ligands

✍ Scribed by Laurent Soulère; Courtney Aldrich; Oliver Daumke; Robert Gail; Lars Kissau; Alfred Wittinghofer; Herbert Waldmann


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
218 KB
Volume
5
Category
Article
ISSN
1439-4227

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Ras-Mediated Cleavage of a GTP Analogue
✍ Robert Gail; Burkhard Costisella; M. Reza Ahmadian; Alfred Wittinghofer 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 106 KB

The small guanosine triphosphate (GTP) binding protein Ras is involved in many cellular signal transduction processes leading to cell growth, differentiation and apoptosis. Mutations in ras genes are found in a large number of human tumours. GTP hydrolysis, the process that normally leads to the tra