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Synthesis of Glycosyl Phosphates from 1,2-Orthoesters and Application to in Situ Glycosylation Reactions

✍ Scribed by Ravidà, Alessandra; Liu, Xinyu; Kovacs, Linda; Seeberger, Peter H.


Book ID
121076811
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
101 KB
Volume
8
Category
Article
ISSN
1523-7060

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The synthesis of the C-glycoside analogue of the disaccharide Man-(a1 32)Man has been achieved in a highly stereoselective and efficient manner employing an approach which closely parallels O-glycoside synthesis. The key step included the samarium diiodide reduction of mannosyl pyridylsulfone 18 in