Synthesis of GA73 methyl ester, a potent gibberellin-derived antheridiogen from gametophytes of the fern lygodium japonicum

✍ Scribed by Petra Kraft-Klaunzer; Mark Furber; Lewis N. Mander; Bruce Twitchin

• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 270 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)97033-3

✦ Synopsis

Iodolactonisation of gibberellin Ag-ene-19-oic acids followed by DBU induced dehydrohalogenation provides good access to gibberellin Ag(lt)-enes, including the potent antheridiogen, Ag(l%iidehydro-GA9 methyl ester (1). isolated from gametophytes of the fern Lygodium japonicum.

Gibberellin Ag (GAg) methyl ester was isolated by the Takahashi group from gametophytes of the fern Lygodium juponicum and shown to induce antheridia formation at lO-lu molar concentrations.1 However, the