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Synthesis of fused isoquinolinones by thermal cyclization of β-phenyl-α-substituted amino heterocyclic compounds

✍ Scribed by G. Winters; N. Di Mola


Book ID
104224438
Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
119 KB
Volume
16
Category
Article
ISSN
0040-4039

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✍ Hiroshi Maruoka; Motoyoshi Yamazaki; Yukihiko Tomioka 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 60 KB

## Abstract The reactions of 2‐amino‐4,5‐dihydro‐3‐furancarbonitriles **1a‐d** with α,β‐unsaturated carbonyl compounds in the presence of sodium ethoxide (0.1 equivalent) gave the corresponding Michael adducts **2a‐d**, **3a‐d** and **4a‐d.** Compounds **2a‐d** and **3a‐c** reacted with sodium alko