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Synthesis of fused 1,2,5-triazepine-1,5-diones and some N2- and N3-substituted derivatives: potential conformational mimetics for cis-peptidyl prolinamides 1

โœ Scribed by Lenman, Morag M.; Lewis, Arwel; Gani, David


Book ID
111949037
Publisher
Royal Society of Chemistry
Year
1997
Weight
245 KB
Volume
16
Category
Article
ISSN
1472-7781

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Synthesis and Photochemistry of 5,5-Dime
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In two steps, 5,Sdimethyl-lH-pyrrol-2(5H)-one (3a) was prepared from 5,5-dimethylpyrrolidine-2,4-dione ( = dimethyltetramic acid; 4) in 71 % overall yield (Scheme 1 ) and further converted to N-substituted derivatives 3b-f viu acylation, alkylation, or methoxycarbonylation of its anion (Scheme 2). T