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Synthesis of fundamental heterocycles C5O-C5N :1 2H-pyrano[3,2-b]pyridine and 2H-pyrano[2,3-c] pyridine.

✍ Scribed by D. Billeret; D. Blondeau; H. Sliwa


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
123 KB
Volume
32
Category
Article
ISSN
0040-4039

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## Abstract An efficient two‐step synthesis of novel 3‐(5‐amino‐[1,3,4]thiadiazol‐2‐yl)‐2__H__‐pyrano[2,3‐__c__]pyridine‐2‐ones was developed. In the first step, a new 2__H__‐pyrano[2,3‐__c__]pyridine‐3‐carboxamide **5** was prepared by Knoevenagel condensation of pyridoxal hydrochloride with cyano