Synthesis of Functionalized γ-Spirolactone and 2-Oxabicyclo[3.3.0]octane Derivatives from Nucleophilic Oxirane Ring Opening
✍ Scribed by Margareth Rôse de L. Santos; Eliezer J. Barreiro; Raimundo Braz-Filho; Carlos Alberto M. Fraga
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 155 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
## Abstract Differently substituted alkynyloxiranes were efficiently converted into functionalized 1,3‐dihydroisobenzofurans and tetrahydrofuran derivatives in fair to good yields by a new cascade reaction, consisting of a sequential nucleophilic ring opening–heterocyclization–oxidative carbonylati
The regiochemical outcome of the ring-opening of epoxides trans epoxides 2 and 4) or predominant (from cis epoxides 1 and 3) ring-opening products. However, under chelating bearing remote polar functionalities has been established in the case of carbocyclic (1 and 2) and the corresponding conditions