Starting from siloxycyclopropyl-substituted dimethyl derivatives 11, 12, 13, cycloeicosanone derivative 16, cyclotetradecanone derivative 19 and cyclononane malonates 1 and 2 a chain elongation was performed to give new malonates 8, 9, 10, and 18 in reasonable overall yield. derivative 22 (together
Synthesis of Functionalized Cyclophanes by Ring-Opening/Ring-Closure Cascade Reactions of Siloxycyclopropanes
✍ Scribed by Astrid Ullmann; Margit Gruner; Hans-Ulrich Reißig
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 280 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0947-6539
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## Abstract Differently substituted alkynyloxiranes were efficiently converted into functionalized 1,3‐dihydroisobenzofurans and tetrahydrofuran derivatives in fair to good yields by a new cascade reaction, consisting of a sequential nucleophilic ring opening–heterocyclization–oxidative carbonylati
The ring-opening reaction of pyridinium salts dates back over a century to the pioneering work of Zincke and König. [1] Activation of pyridines as their pyridinium salts renders the heterocycle electrophilic at the 2-and 4-positions and enables a diverse range of productive chemistry, with or withou