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Synthesis of Functionalized Cyclohexadiene-trans-Diols with Recombinant Cells of Escherichia coli

✍ Scribed by Dirk Franke; Georg A. Sprenger; Michael Müller

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
78 KB
Volume
40
Category
Article
ISSN
0044-8249

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✦ Synopsis

As valuable chiral building blocks for the syntheses of natural products and pharmacologically active substances, especially of carbohydrate mimetics, functionalized cyclohexadiene-trans-diols such as (2S,3S)-dihydroxy-2,3-dihydrobenzoic acid (1) can be prepared easily in 17 % yield starting from glucose by using metabolically deregulated, recombinant microorganisms such as the Escherichia coli strain AN193.

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