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Synthesis of functionalized 1,2,3-triazole derivatives of 2-indolones from Morita-Baylis-Hillman adducts of isatin via “click chemistry”

✍ Scribed by Ponnusamy Shanmugam; Mumusamy Damodiran; Kodirajan Selvakumar; Paramasivan T. Perumal

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
98 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A short and efficient regioselective synthesis of a number of 1,4‐disubstituted‐1,2,3‐triazole derivatives of oxindoles from N‐terminal alkyne and alkynyl ether derivatives of Morita‐Baylis‐Hillman (MBH) adducts of isatin with in situ generated alkyl azide and copper(I) iodide as a catalyst in 1:1 mixture of t‐BuOH:water as a solvent system has been achieved. The synthetic procedure tolerates most of the functional groups present in the MBH adducts and circumvents the problems associated with the isolation of potentially toxic and explosive organic azides. J. Heterocyclic Chem., (2009).

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ChemInform Abstract: Synthesis of Functi
ChemInform Abstract: Synthesis of Functionalized 1,2,3-Triazole Derivatives of 2-Indolones from Morita—Baylis—Hillman Adducts of Isatin via “Click Chemistry”.
✍ Ponnusamy Shanmugam; Mumusamy Damodiran; Kodirajan Selvakumar; Paramasivan T. Pe 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

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