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Synthesis of Four Novel Natural Product Inspired Scaffolds for Drug Discovery

✍ Scribed by Jenkins, Ian D.; Lacrampe, Fabienne; Ripper, Justin; Alcaraz, Lilian; Van Le, Phuc; Nikolakopoulos, George; de Almeida Leone, Priscila; White, Rodney H.; Quinn, Ronald J.


Book ID
120198394
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
500 KB
Volume
74
Category
Article
ISSN
0022-3263

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A Novel Approach in Drug Discovery: Synt
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Hetero-Diels-Alder reaction of the steroidal exocyclic enol ethers 14 and 15, obtained from the secoestrones 8 and 9 by reduction, iodoetherification, and elimination, with ethyl O-benzoyldiformylacetate (16) leads to the spiroacetals 17 and 18 as a mixture of four diastereomers. Reduction of the ma