Synthesis of Fmoc-amino acid fluorides via DAST, an alternative fluorinating agent

✍ Scribed by Christine Kaduk; Holger Wenschuh; Michael Beyermann; Klaus Forner; Louis A. Carpino; Michael Bienert

• Book ID: 104639614
• Publisher: Springer Netherlands
• Year: 1996
• Tongue: English
• Weight: 251 KB
• Volume: 2
• Category: Article
• ISSN: 1573-3149
• DOI: 10.1007/bf00142240

✦ Synopsis

DAST [(diethylamino)sulfur trifluoride] has shown to be an excellent alternative fluorinating agent for synthesis of Fmoc-amino acid fluorides. The use of DAST is advantageous relative to other fluorinating agents, such as cyanuric fluoride, since handling and isolation of the acid fluorides are facile.