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Synthesis of (Fluoroalkyl)amines by Deoxyfluorination of Amino Alcohols.

✍ Scribed by Takashi Nomoto; Tsuyoshi Fukuhara; Shoji Hara


Publisher
John Wiley and Sons
Year
2006
Weight
25 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract A practical and selective method for the synthesis of the β‐arylamines 5 and the __cis__‐ or __trans__‐amino alcohols 8 or 11 is reported. The reaction sequence starts from α‐tetralones 1 which readily react with dibenzyl azodicarboxylate to afford the protected α‐hydrazino ketones 2. T