𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of flavonol derivatives as probes of biological processes

✍ Scribed by Hiroko Tanaka; Michelle M Stohlmeyer; Thomas J Wandless; Loverine P Taylor

Book ID
104211314
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
63 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Two synthetic derivatives of the flavonol kaempferol were prepared in order to probe the biological mechanism of action of this natural product. Efficient synthetic routes to both a benzophenone-containing derivative and an amine-containing derivative are reported herein.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Flavon
ChemInform Abstract: Synthesis of Flavonol Derivatives as Probes of Biological Processes.
✍ Hiroko Tanaka; Michelle M. Stohlmeyer; Thomas J. Wandless; Loverine P. Taylor πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Synthesis and biological evaluation of i
Synthesis and biological evaluation of indole-chalcone derivatives as Ξ²-amyloid imaging probe
✍ Mengchao Cui; Masahiro Ono; Hiroyuki Kimura; Bo Li Liu; Hideo Saji πŸ“‚ Article πŸ“… 2011 πŸ› Elsevier Science 🌐 English βš– 468 KB

A series of chaclone derivatives containing an indole moiety were evaluated in competitive binding assays with AΞ²(1-42) aggregates versus [(125)I]IMPY. The affinity of these compounds ranged from 4.46 to >1008 nM, depending on the substitution on the phenyl ring. Fluorescent staining in vitro showed