Synthesis of Ethyl 3-Amino-5-arylthiophene-2-carboxylates Based on α-Chlorocinnamonitriles.
✍ Scribed by A. V. Shastin; I. V. Golubinskii; O. N. Lenkova; E. S. Balenkova; V. G. Nenaidenko
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 15 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The reaction of 2‐amino‐4,5‐dihydro‐3‐thiophenecarbonitriles 1a–c with ethyl acetoacetate in the presence of titanium(IV) chloride gave the corresponding ethyl 4‐amino‐2,3‐dihydro‐6‐methylthieno[2,3‐__b__]pyridine‐5‐carboxylates 3a–c. Similarly, compounds 1a–c reacted with diethyl malon