𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Ethyl 2-Methylene-3-aryl-4-oxoalkanoates and Ethyl 2-Arylidene-4-oxoalkanoates from the Baylis—Hillman Acetates.

✍ Scribed by Jeong Mi Kim; Yang Jin Im; Taek Hyeon Kim; Jae Nyoung Kim

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Reactions of 4-Oxoalkanoic Acids, 4. Syn
Reactions of 4-Oxoalkanoic Acids, 4. Synthesis of (±)-6-Alkyl-5-oxa-1-azabicyclo[4.3.0]nonan-9-ones, (±)-5-Alkyl-4-oxa-1-azabicyclo[3.3.0]octan-8-ones, and Substituted 1,6-Dioxa-3,8-diazacyclodecanes by Reaction of Ethyl 4-Oxoalkanoates with 3-Aminopropanol and 2-Aminoethanol
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, Günter 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Å in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (±)‐5‐alkyl‐4‐oxa‐1‐azab

Synthesis and analgesic-antiinflammatory
Synthesis and analgesic-antiinflammatory activities of ethyl 2-[3-(1-phenoxy(methoxy)carbonyl-4-aryl-(alkyl)-1,4-dihydropyridyl)]acetates
✍ Sammy A. Agudoawu; Edward E. Knaus 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 291 KB

## Abstract Reaction of ethyl 2‐(3‐pyridyl)acetate **4a** or ethyl 2‐methyl‐2‐(3‐pyridyl)acetate **4b**, with phenyl chloroformate or methyl chloroform ate, afforded the intermediate pyridinium salt **5** which undergoes regioselective nucleophilic attack at C‐4 upon reaction with a Grignard reagen