Synthesis of ethyl 2-aminodihydro-5-pyrimidinecar-boxylate derivatives and 3,7-diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-1H-pyrimido[1,2-a]pyrimidines
✍ Scribed by René Milcent; Jean-Claude Malanda; Géo Barbier; Jacqueline Vaissermann
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1997
- Tongue
- English
- Weight
- 440 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Reactions of ethyl 3‐aryl‐2‐benzoylpropenoates 1 with guanidine and N‐alkyl(or benzyl)guanidines have been investigated. Ethyl 2‐aminodihydro‐5‐pyrimidinecarboxylate derivatives 3, 4 or 5, and 3,7‐diethoxy‐carbonyl‐4,6‐dihydro‐2,4,6,8‐tetraaryl‐1__H__‐pyrimido[1,2‐a]pyrimidines 6 have been synthesized.
📜 SIMILAR VOLUMES
## Abstract The 6‐(3‐hydroxypropylamino)‐3‐methylpyrimidine‐2,4‐dione (1) did not afford the expected 6‐(3‐chloro‐propylamino)‐ derivative on reaction with thionyl chloride, but, instead, the pyrimidine rings were joined __via__ a sulfur bridge to give 9,9′‐thiobis(1,2,3,4,7,8‐hexahydro‐7‐melnyl‐6_