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Synthesis of Enantiopure Substituted Piperidines via an Aziridinium Ring Expansion

โœ Scribed by Jarvis, Scott B. D.; Charette, Andre B.


Book ID
111879605
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
773 KB
Volume
13
Category
Article
ISSN
1523-7060

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The additions of lithiated allylsulfone carbanion to chiral N-sulfinylimines were found to proceed with good to excellent selectivity. The resulting intermediates 4a-d after transformation to dienylamides 7a-d and 16a-d, were converted to functionalized enantiopure piperidines and pyrrolines, respec