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Synthesis of enantiopure aza-analogues of cocaine

✍ Scribed by N.Miranda Teerhuis; Henk Hiemstra; W.Nico Speckamp

Book ID: 104255992
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 241 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02242-3

No coin nor oath required. For personal study only.

✦ Synopsis

An enantiopure aza-analogue of pseudo-cocaine was synthesized starting from a 5-substituted 3-pyrazolidinone by using an N-acylhydrazonium ion cyclization with a dioxenone nucleophile as the key step.

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